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prostacyclin receptor; prostanoid IP receptor; PGI receptor; prostaglandin I2 receptor (PTGIR, PRIPR)
Function:
- receptor for prostacyclin (prostaglandin I2 or PGI2)
- activity is mediated by Gs proteins which activate adenylate cyclase
Structure:
- palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to Gs & signaling
- isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase & phospholipase C
- belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
glycoprotein
prenyl protein
prostaglandin receptor
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 386 aa
MW = 41 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-16}
MOTIF: cysteine residue {C5}
MODIFICATION: cysteine residue {C165}
N-glycosylation site {N7}
transmembrane domain {17-38}
cytoplasmic loop {39-51}
transmembrane domain {52-76}
exoplasmic loop {77-94}
MOTIF: cysteine residue {C92}
MODIFICATION: cysteine residue {C170}
transmembrane domain {95-115}
cytoplasmic loop {116-134}
transmembrane domain {135-158}
exoplasmic loop {159-181}
MOTIF: cysteine residue {C165}
MODIFICATION: cysteine residue {C5}
cysteine residue {C170}
MODIFICATION: cysteine residue {C92}
transmembrane domain {182-208}
cytoplasmic loop {209-235}
transmembrane domain {236-260}
exoplasmic loop {261-274}
transmembrane domain {275-295}
cytoplasmic domain {296-386}
MOTIF: cysteine residue {C308}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {309}
cysteine residue {C311}
MODIFICATION: palmitate
COMPARTMENT: membrane
CaaX motif
SITE: C383
EFFECTOR-BOUND: farnesyl
Database Correlations
OMIM 600022
UniProt P43119
Pfam PF00001
Kegg hsa:5739
References
- UniProt :accession P43119
- Marcus AJ, Safier LB.
Thromboregulation: multicellular modulation of platelet
reactivity in hemostasis and thrombosis.
FASEB J. 1993 Apr 1;7(6):516-22. Review.
PMID: 8472890