propionyl CoA carboxylase

Function: - carbohydrate metabolism; propanoate metabolism ATP + propanoyl-CoA + HCO₃^- ADP + phosphate + (S)-methylmalonyl-CoA Structure: - probably a dodecamer composed of six biotin-containing alpha subunits & six beta subunits

General

allosteric enzyme ligase or synthetase multisubunit protein phosphoprotein

Properties

MOTIF: active site phosphorylation site allosteric site SUBUNITS: propionyl CoA carboxylase-alpha chain MOTIF: Biotin carboxylation {37-484} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 152-152 ATP-grasp domain SITE: 156-353 ATP-binding site NAME: ATP-binding site SITE: 236-236 ATP-binding site NAME: ATP-binding site SITE: 271-271 arginine residue {R328} Ser phosphorylation site {S467} binding site SITE: 635-702 FOR-BINDING-OF: BIOTINYL MOTIF: binding site SITE: 669-669 FOR-BINDING-OF: biotin propionyl CoA carboxylase-beta chain MOTIF: Carboxyltransferase {38-531} MOTIF: Acyl-CoA binding {325-358}

Components

propionyl CoA carboxylase-alpha chain (PCCA) propionyl CoA carboxylase-beta chain (PCCB)