proline-rich region

Proline-rich regions may serve as binding sites for SH3 (src-homology 3) domains. They may also serve as sites for phosphorylation by proline-directed protein kinases. Phosphorylation may alter the binding with SH3-domains. The proline-rich regions may also contain a motif PPXXF which serves to bind the EVH1 domain of homer.

General

binding site specific amino acid-enriched region (low complexity region)

Properties

MOTIF: proline residue (SEVERAL)

References

- Pawson T Protein modules and signalling networks Nature 373:573 1995 (Notch) PMID: 7531822