proline-directed protein kinase

Function: - serine/threonine kinases with a specificity for Ser-Pro & Thr-Pro

Specific

ceramide-activated protein kinase glycogen synthase kinase 3 (GSK3) mitogen-activated protein kinase (MAP kinase) or microtubule-associated protein kinase

Properties

STATE: active state MOTIF: S/T phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site MISC-INFO: RECOGNITION-MOTIF :SEQUENCE X[S*]PX X[T*]PX :REF " - Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: 2238044"

References

- Goedert M. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci. 1993 Nov;16(11):460-5. Review. PMID: 7507619