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prolactin; lactogenic hormone (PRL)
Function:
- the major function of prolactin is in conjunction with a variety of other hormones to promote breast development & to initiate lactation in women
- there is no known physiological function in men
Structure:
- single chain polypeptide hormone
Compartment: secreted
Expression:
- secreted from the anterior pituitary gland
- dopaminergic tuberoinfundibular system inhibits prolactin secretion by pituitary lactotrophs
Pathology:
- disorders in prolactin secretion are associated with hyperprolactinemia
Related
hyperprolactinemia
pituitary adenoma/prolactin secreting (prolactinoma)
prolactin Ag in tissue
prolactin gene
prolactin in serum
prolactin receptor; PRL-R (PRLR)
General
pituitary gonadotropin
Properties
COMPARTMENT: plasma
MOTIF: N-glycosylation site {N59}
cysteine residue {C219}
MODIFICATION: cysteine residue {C227}
cysteine residue {C227}
MODIFICATION: cysteine residue {C219}
Database Correlations
OMIM 176760
UniProt P01236
Entrez Gene 5617
References
- Entrez Gene :accession 5617