Search
proinsulin
Precursor to insulin synthesized in beta-cells of the pancreatic islets of Langerhans. Its synthesis & formation of disulfide bonds occurs in the endoplasmic reticulum. It is then transported to the Golgi where it is packaged into secretory granules & processed by a series of peptidases/proteases to form mature insulin, C-peptide & 4 amino acids.
Peptidases processing proinsulin include:
- carboxypeptidase E
Properties
GENERAL: insulin protein
QUALITIES: lifetime
:VALUE RANGE
:LOW 15
:HIGH 30
:UNITS MIN
:FORM 1/2-LIFE
COMPARTMENT: extracellular compartment
Database Correlations
UniProt P01308
References
- Fundamentals of Clinical Chemistry 3rd ed., N.W.
Teitz ed., W.B. Saunders, 1988, pg 544
- Clinical Diagnosis & Management by Laboratory Methods,
J.B. Henry (ed), W.B. Saunders Co., Philadelphia,
PA. 1991, pg 172