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proglucagon
Function:
- precursor for
- glucagon
- glucagon-like peptide 1
- glucagon-like peptide 2
- oxyntomodulin
- glicentin
- post-translationally processed in a tissue-specific manner in pancreatic A cells & intestinal L cells
- in pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2
- in intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin & oxyntomodulin
General
glucagon; contains: glicentin; glicentin-related polypeptide; GRPP; oxyntomodulin; OXM; OXY; glucagon-like peptide 1; GLP-1; glucagon-like peptide 1(7-37); GLP-1(7-37); glucagon-like peptide 1(7-36); GLP-1(7-36); glucagon-like peptide 2; GLP-2 (GCG)
peptide precursor
Properties
SIZE: entity length = 180 aa
MW = 21 kD
COMPARTMENT: plasma
SECRETED-BY: alpha cell
WITHIN: islets of Langerhans
MOTIF: signal sequence {1-20}
proteolytic site
PRECURSOR-FOR: glucagon
COMPARTMENT: plasma
SECRETED-BY: alpha cell
WITHIN: islets of Langerhans
MOTIF: signal sequence {1-20}
proteolytic site {52-53}
proteolytic site {83-84}
proteolytic site {91-92}
proteolytic site {97-98}
proteolytic site {130-131}
proteolytic site {145-146}
glucagon-like peptide 1
COMPARTMENT: plasma
SECRETED-BY: endocrine cell
WITHIN: intestine
glucagon-like peptide 2
COMPARTMENT: extracellular compartment
oxyntomodulin
COMPARTMENT: extracellular compartment
glicentin
COMPARTMENT: extracellular compartment
Database Correlations
OMIM 138030
UniProt P01275
References
- Holz CG & Habener JF
Signal transduction crosstalk in the endocrine system:
pancreatic beta-cells and the glucose competence concept.
TIBS 17:388 1992
PMID: 1455507
- UniProt :accession P01275