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Progesterone receptor; PR; nuclear receptor subfamily 3 group C member 3 (PGR, NR3C3)
Function:
- nuclear hormone receptor
- interacts with CUEDC2, SMARD1 & with UNC45A
- cytoplasmic anchoring &/or assembly associated with heat shock proteins hsp70 & hsp90 & immunophilin p59FKBP
Structure:
- composed of three domains:
a) modulating N-terminal domain
b) DNA-binding domain
c) C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR3 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Related
Estrogen+Progesterone receptor Ag in tissue
FK506-binding protein 4 (52 kD FK506 binding protein, hsp-binding immunophilin, FKBP59, FKBP4)
heat shock protein [hsp] 70, HSP70A or HSP-A
heat shock protein [hsp]-90
hormone (estrogen) receptor status panel
membrane progestin receptor gamma (mPR gamma, progestin & adipoQ receptor family member V, PAQR5, MPRG)
membrane-associated progesterone receptor component 1; mPR (PGRMC1, HPR66, PGRMC)
membrane-associated progesterone receptor component 2; progesterone membrane-binding protein; steroid receptor protein DG6 (PGRMC2, DG6, PMBP)
progesterone (Progestasert, Prometrium, Pro-Gest, Prochieve)
General
PEST protein
steroid receptor
Properties
SIZE: MW = 99 kD
entity length = 933 aa
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S20}
Ser phosphorylation site {S25}
Thr phosphorylation site {T41}
FOR-PHOSPHORYLATION-BY: casein kinase
Ser phosphorylation site {S102}
Ser phosphorylation site {S130}
Ser phosphorylation site {S162}
nuclear translocation signal {183-187}
PEST region
MOTIF: Ser phosphorylation site {S190}
Ser phosphorylation site {S213}
Ser phosphorylation site {S227}
FOR-PHOSPHORYLATION-BY: casein kinase
Ser phosphorylation site {S232}
FOR-PHOSPHORYLATION-BY: casein kinase
Ser phosphorylation site {S345}
Thr phosphorylation site {T430}
Ser phosphorylation site {S552}
FOR-PHOSPHORYLATION-BY: casein kinase
Ser phosphorylation site {S554}
DNA-binding motif
SITE: 567-639
MOTIF: Zn finger C4-type
SITE: 567-587
EFFECTOR-BOUND: Zn+2
kxffkr
NAME: kxffkr
SITE: 588-593
FOR-BINDING-OF: calreticulin
FORM: kxffkr
Zn finger C4-type
SITE: 603-627
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S676}
ligand-binding site
SITE: 681-933
FOR-BINDING-OF: progesterone
MOTIF: Ser phosphorylation site {S793}
FOR-PHOSPHORYLATION-BY: casein kinase
Database Correlations
OMIM 607311
UniProt P06401
PFAM correlations
Entrez Gene 5241
Kegg hsa:5241
References
- Alberts et al Molecular Biology of the Cell, 2nd ed.
1989, pg 704
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA, Hankinson O.
Cloning of a factor required for activity of the Ah (dioxin) receptor.
Science. 1991 May 17;252(5008):954-8.
PMID: 1852076
- Progesterone receptor entry
http://en.wikipedia.org/wiki/Progesterone_receptor
- UniProt :accession P06401