Search
procalcitonin; contains: calcitonin, katacalcin; calcitonin carboxyl-terminal peptide; CCP; PDN-21 (CALCA, CALC1)
Function:
1) precursor to calcitonin
2) precursor to katacalcin
Structure: belongs to the calcitonin family
Compartment: secreted
Alternative splicing:
- named isoforms=3
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Laboratory:
- serum procalcitonin appears to be a marker of bacterial infection
Properties
GENERAL: calcitonin
RELATED: CALC1
procalcitonin in serum
SIZE: entity length = 141 aa
MW = 15 kD
COMPARTMENT: extracellular compartment
SECRETED-BY: parafollicular cell
WITHIN: thyroid
FORM: procalcitonin
MOTIF: signal sequence {1-25}
cysteine residue {C85}
MODIFICATION: cysteine residue {C91}
cysteine residue {C91}
MODIFICATION: cysteine residue {C85}
MISC-INFO: elimination route PLASMA
1/2life 1 HOURS
pregnancy-category C
safety in lactation ?
Database Correlations
OMIM 114130
UniProt P01258
Pfam PF00214
Entrez Gene 796
Kegg hsa:796
References
- UniProt :accession P01258
- NIEHS-SNPs
http://egp.gs.washington.edu/data/calca/
- Wikipedia; Note: calcitonin entry
http://en.wikipedia.org/wiki/calcitonin