prolactin-releasing peptide receptor; PrRP receptor; PrRPR; G-protein coupled receptor 10; hGR3 (PRLHR, GPR10, GR3)

Function: - receptor for prolactin-releasing peptide (PrRP) - implicated in lactation, regulation of food intake & pain-signal processing - interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 & PICK1 - interacts with PDZ domains 4 & 5 of GRIP1 & with the PDZ domain of PICK1 Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - only detected in the pituitary gland & in all cell types of pituitary adenomas - repressed by bromocriptine, a dopamine agonist

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 370 aa MW = 41 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-62} MOTIF: N-glycosylation site {N27} N-glycosylation site {N36} transmembrane domain {63-83} cytoplasmic loop {84-101} transmembrane domain {102-122} exoplasmic loop {123-126} transmembrane domain {127-147} MOTIF: cysteine residue {C134} MODIFICATION: cysteine residue {C211} cytoplasmic loop {148-175} transmembrane domain {176-196} exoplasmic loop {197-225} MOTIF: cysteine residue {C211} MODIFICATION: cysteine residue {C134} transmembrane domain {226-246} cytoplasmic loop {247-276} transmembrane domain {277-297} exoplasmic loop {298-317} transmembrane domain {318-338} cytoplasmic domain {339-369} GRIP1, GRIP2 & PICK1 interaction {365-370}

Database Correlations

OMIM 600895 UniProt P49683 Pfam PF00001 Entrez Gene 2834 Kegg hsa:2834

References

UniProt :accession P49683