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PRKDC complex
Components:
- G22P1/KU70, XRCC5/KU80 PRKDC/XRCC7
General
molecular complex
Properties
SUBUNITS: X-ray repair cross-complementing protein 6
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {2-61}
MOTIF: serine residue (SEVERAL)
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S6}
acidic region {11-29}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S27}
lysine residue {K31}
Ser phosphorylation site {S51}
Ser phosphorylation site {S222}
Ku {261-468}
MOTIF: acidic region {330-342}
MOTIF: acidic residue (SEVERAL)
Thr phosphorylation site {T455}
Ser phosphorylation site {S520}
SAP {573-607}
X-ray repair cross-complementing protein 5
COMPARTMENT: cell nucleus
MOTIF: leucine zipper
SITE: 138-165
FOR-BINDING-VIA: leucine zipper
Ku {251-460}
MOTIF: Ser phosphorylation site {S258}
proline-rich region
SITE: 478-519
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S577}
Ser phosphorylation site {S579}
Ser phosphorylation site {S580}
Thr phosphorylation site {T715}
EEXXXDL {720-728}
DNA-dependent protein kinase catalytic subunit
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
HEAT repeat {288-323}
Ser phosphorylation site {S511}
Ser phosphorylation site {S841}
Ser phosphorylation site {S893}
HEAT repeat {1004-1040}
Ser phosphorylation site {S1052}
leucine zipper
SITE: 1503-1538
FOR-BINDING-VIA: leucine zipper
MOTIF: C1D interaction {1503-1538}
tetratricopeptide repeat {1723-1756}
proteolytic site {2020-2021}
Ser phosphorylation site {S2117}
binding site
SITE: 2436-3212
FOR-BINDING-OF: Ca+2 & integrin-binding protein 1
MOTIF: Thr phosphorylation site {T2603}
Thr phosphorylation site {T2609}
Ser phosphorylation site {S2612}
Thr phosphorylation site {T2638}
Thr phosphorylation site {T2647}
Thr phosphorylation site {T2649}
Thr phosphorylation site {T2671}
Ser phosphorylation site {S2672}
Tyr phosphorylation site {Y2743}
FAT domain
NAME: FAT domain
SITE: 2883-3539
MOTIF: Tyr phosphorylation site
binding site
FOR-BINDING-OF: Paxillin
tetratricopeptide repeat {2920-2948}
tetratricopeptide repeat {2949-2982}
Ser phosphorylation site {S3205}
PI3K/PI4K {3747-4015}
Ser phosphorylation site {S4026}
FATC {4096-4128}
STATE: active state
References
UniProt :accession Q14676
Components
DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460 (PRKDC, HYRC, HYRC1)
X-ray repair cross-complementing protein 5; 86 kD subunit of Ku antigen; p86Ku; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kD subunit; CTC box-binding factor 85 kD subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Lupus Ku autoantigen protein p86; nuclear factor IV; thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in chinese hamster cells 5 (double-strand-break rejoining) (XRCC5, G22P2)
X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kD subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kD subunit; CTC box-binding factor 75 kD subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in chinese hamster cells 6 (XRCC6, G22P1)