Search
protein kinase (C-mu protein kinase D1, PRKD1, PKD, PKD1, PRKCM)
Function:
- Ca+2-independent, phospholipid-dependent
- serine/threonine kinase
- interacts via its N-terminal region with CENTA1
- activated by diacylglycerol & phorbol esters
- autophosphorylated (putative)
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKC subfamily
- contains 1 PH domain
- contains 2 phorbol-ester/DAG-type Zn+2 fingers
- contains 1 protein kinase domain
General
protein kinase C (PKC)
zinc finger protein
Properties
SIZE: entity length = 912 aa
MW = 102 kD
COMPARTMENT: plasma membrane*
CELL: most cell types*
ORGANISM: eukaryote*
MOTIF: alanine-rich region {17-26}
MOTIF: alanine residue (SEVERAL)
Zinc finger
NAME: Zinc finger
SITE: 146-196
EFFECTOR-BOUND: Zn+2
arginine-rich region {200-203}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S205}
Thr phosphorylation site {T210}
Zinc finger
NAME: Zinc finger
SITE: 270-320
EFFECTOR-BOUND: Zn+2
PH domain {422-541}
kinase domain
SITE: 583-839
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 589-597
ATP-binding site
NAME: ATP-binding site
SITE: 612-612
aspartate residue {D706}
Ser phosphorylation site {S910}
STATE: active state
Database Correlations
OMIM 605435
UniProt Q15139
PFAM correlations
Entrez Gene 5587
Kegg hsa:5587
ENZYME 2.7.11.13
References
- UniProt :accession Q15139
- Atlas of genetics & cytogenetics in oncology & Haematology
http://atlasgeneticsoncology.org/genes/PRKCMID41860ch14q11.html