protein kinase C-gamma (PKC-I, PRKCG, PRKCC)

Function: - Ca⁺²-activated, phospholipid-dependent - serine/threonine kinase - activated by diacylglycerol - phosphorylates a range of cellular proteins - interacts with CDCP1 Cofactor: - binds 3 Ca⁺² per subunit - Ca⁺² are bound to the C2 domain (putative) Structure: - belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily - contains 1 AGC-kinase C-terminal domain - contains 1 C2 domain - contains 2 phorbol-ester/DAG-type Zn⁺² fingers - contains 1 protein kinase domain Pathology: - defects associated with spinocerebellar ataxia type 14 (may be due to mutation rather than CAG repeat expansion) Laboratory: - PRKCG gene CAG repeats*

Properties

SIZE: entity length = 697 aa MW = 78 kD COMPARTMENT: plasma membrane* CELL: most cell types* ORGANISM: eukaryote* STATE: active state MOTIF: Zinc finger NAME: Zinc finger SITE: 35-85 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 100-150 EFFECTOR-BOUND: Zn+2 C2 domain {170-260} MOTIF: binding site FOR-BINDING-OF: phospholipid Ca+2-binding site SITE: 186-186 Ca+2-binding site SITE: 187-187 Ca+2-binding site SITE: 193-193 Tyr phosphorylation site {Y195} Ca+2-binding site SITE: 246-246 Ca+2-binding site SITE: 247-247 Ca+2-binding site SITE: 248-248 Ca+2-binding site SITE: 251-251 Ca+2-binding site SITE: 252-252 Ca+2-binding site SITE: 254-254 Tyr phosphorylation site {Y312} Ser phosphorylation site {S322} Ser phosphorylation site {S330} kinase domain SITE: 351-614 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 357-365 ATP-binding site NAME: ATP-binding site SITE: 380-380 aspartate residue {D480} Thr phosphorylation site {T514} Thr phosphorylation site {T518} AGC-kinase C-terminal {615-685} MOTIF: Thr phosphorylation site {T648} Thr phosphorylation site {T655} Ser phosphorylation site {S687} MISC-INFO: RECOGNITION-MOTIF :SEQUENCE XRXX[S*]XRX :REF " - Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: 2238044" INHIBITOR = SPHINGOSINE

Database Correlations

OMIM correlations MORBIDMAP 176980 UniProt P05129 PFAM correlations Entrez Gene 5582 KEGG correlations