PRKCA-binding protein; protein interacting with C kinase 1; protein kinase C-alpha-binding protein (PICK1, PRKCABP)

Function: - probable adapter protein - binds & organizes subcellular localization of membrane proteins containing some PDZ recognition sequence - role in clustering of receptors, possibly by acting at the receptor internalization level - may be regulated upon PRKCA activation - may regulate ACCN3-ACCN2 heteromeric cation channel - interacts presynaptically with: a) monoamine transporters SLC6A2 & SLC6A3 b) channel proteins ACCN1 & ACCN2 c) GTP-binding proteins ARF1 & ARF3 - interacts with PRKCA - interacts with the ephrin receptor tyrosine kinases EPHA7, EPHB1 & EPHB2 - interacts with ERBB2 - interacts with BTG2 - interacts with the glutamate receptors GRIA2, GRIA3 - interacts with GRM4 (isoform A), GRM7 & GRM8 - interacts with NAPA & NAPB; interaction with NAPA & NAPB disrupts the interaction with GRIA2 & its internalization - interacts with UNC5A - interacts with CXADR - interacts through its PDZ domain with the C-terminal tail of PRLHR - interacts (via AH domain) with NCS1/FREQ (Ca⁺²-dependent) Structure: - monomer & homodimer - contains 1 AH domain - contains 1 PDZ domain (DHR domain) Compartment: - cytoplasm, perinuclear region - cell junction, synapse - present at excitatory synapses Expression: ubiquitous

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 415 aa MW = 47 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T18} PDZ domain NAME: PDZ domain SITE: 22-105 AH {144-357} glutamate-rich region {382-388} MOTIF: glutamate residue (SEVERAL)

Database Correlations

OMIM 605926 UniProt Q9NRD5 PFAM correlations Entrez Gene 9463 Kegg hsa:9463

References

UniProt :accession Q9NRD5