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protein kinase A2 [PKA2] regulatory subunit-beta (PRKAR2B)
Function:
- type 2 regulatory chain
- may mediate membrane association by binding to anchoring proteins
- binds four cAMP molecules
- phosphorylated by the activated catalytic chain
Structure:
- belongs to the cAMP-dependent kinase regulatory chain family
- contains 2 cyclic nucleotide-binding domains
Related
protein kinase A2
General
protein kinase A2 [PKA2] regulatory subunit; AKAP5; A-kinase anchor protein 79; AKAP-79 (PKA2R)
Properties
SIZE: entity length = 418 aa
MW = 46 kD
COMPARTMENT: cytoplasm
MOTIF: Dimerization and phosphorylation {2-153}
MOTIF: Ser phosphorylation site {S114}
cAMP-binding site
SITE: 154-275
MOTIF: cAMP-binding site
SITE: 223-223
cAMP-binding site
SITE: 232-232
cAMP-binding site
SITE: 276-418
MOTIF: cAMP-binding site
SITE: 352-352
cAMP-binding site
SITE: 361-361
Database Correlations
OMIM 176912
UniProt P31323
PFAM correlations
Kegg hsa:5577
References
UniProt :accession P31323