protein kinase A2 [PKA2] regulatory subunit-alpha (PRKAR2A)

Function: - type 2 regulatory chain - may mediate membrane association by binding to anchoring proteins - interacts with AKAP4 & CBFA2T3 - phosphorylated by the activated catalytic chain Structure: - belongs to the cAMP-dependent kinase regulatory chain family - contains 2 cyclic nucleotide-binding domains Expression: - four types of regulatory chains are found: I-alpha, I-beta, II-alpha, & II-beta - their expression varies among tissues & is in some cases constitutive & in others inducible

Properties

SIZE: entity length = 404 aa MW = 46 kD COMPARTMENT: cytoplasm MOTIF: Dimerization and phosphorylation {2-138} MOTIF: Thr phosphorylation site {T54} Ser phosphorylation site {S58} Ser phosphorylation site {S78} Ser phosphorylation site {S80} Ser phosphorylation site {S99} cAMP-binding site SITE: 139-260 MOTIF: cAMP-binding site SITE: 208-208 cAMP-binding site SITE: 217-217 cAMP-binding site SITE: 261-404 MOTIF: cAMP-binding site SITE: 338-338 cAMP-binding site SITE: 347-347

Database Correlations

OMIM 176910 UniProt P13861 PFAM correlations Kegg hsa:5576

References

UniProt :accession P13861