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primase
Function:
- DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication
Structure:
- heterodimer of a small subunit (PRIM1) & a large subunit (PRIM2)
General
RNA polymerase
Properties
COMPARTMENT: cell nucleus
MOTIF: active site
SUBUNITS: DNA primase 49 kD subunit
MOTIF: glutamate residue {E44}
aspartate residue {D109}
aspartate residue {D111}
Zinc finger
NAME: Zinc finger
SITE: 121-131
EFFECTOR-BOUND: Zn+2
DNA primase 58 kD subunit
MOTIF: Tyr phosphorylation site {Y381}
References
- Linn S
How many pols does it take to replicate nuclear DNA?
Cell 66:185 1991
PMID: 1855251
- UniProt :accession P496431
Component-of
DNA polymerase alpha
Components
DNA polymerase alpha 49 kD subunit (DNA primase small subunit, PRIM1)
DNA polymerase alpha 58 kD subunit (DNA primase large subunit, PRIM2)