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prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1, PRICKLE1, RILP)
Function:
1) interacts with REST, necessary for nuclear localization of REST
2) nuclear receptor (putative)
Structure:
- prenylated on Cys-828
- contains 3 LIM zinc-binding domains
- contains 1 PET domain
Compartment:
- nucleus, nuclear membrane
- a smaller amount is detected in the cytosol
Expression:
- expressed in placenta > brain, lung, liver, kidney, pancreas
General
prenyl protein
Properties
SIZE: MW = 94 kD
entity length = 831 aa
COMPARTMENT: cytoplasm
nuclear membrane
MOTIF: PET {14-118}
LIM domain {124-189}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {189-249}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {249-313}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
histidine-rich region {655-682}
MOTIF: histidine residue (SEVERAL)
serine-rich region {761-772}
MOTIF: serine residue (SEVERAL)
lysine-rich region {816-821}
MOTIF: lysine residue (SEVERAL)
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: farnesyl
BOUND-VIA: cysteine residue
Database Correlations
OMIM 608500
MORBIDMAP 608500
UniProt Q96MT3
PFAM correlations
References
UniProt :accession Q96MT3