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prodynorphin; proenkephalin-B; beta-neoendorphin-dynorphin; preprodynorphin; contains: alpha-neoendorphin; contains: beta-neoendorphin; contains: big dynorphin; big dyn; contains: dynorphin A(1-17); dynorphin A; dyn-A17; contains: dynorphin A(1-13); contains: dynorphin A(1-8); contains: Leu-enkephalin; contains: rimorphin; dynorphin B; dyn-B; dynorphin B(1-13); contains: leumorphin; dynorphin B-29 (PDYN)

Function: - Leu-enkephalins compete with & mimic the effects of opiate drugs; they play a role in a number of physiologic functions, including: a) pain perception b) responses to stress - dynorphin peptides differentially regulate the kappa opioid receptor; dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (putative) - Leumorphin has a typical opiod activity & may have anti-apoptotic effect (putative) Structure: - the N-terminal domain contains 6 conserved Cys thought to be involved in disulfide bonding &/or processing - belongs to the opioid neuropeptide precursor family Compartment: secreted

Related

prodynorphin gene or proenkephalin B gene

General

peptide precursor

Properties

SIZE: entity length = 254 aa MW = 28 kD MOTIF: signal sequence {1-20} PRECURSOR-FOR: dynorphin-A dynorphin-B alpha-neoendorphin beta-neoendorphin leucine enkephalin

Database Correlations

OMIM 131340 UniProt P01213 Pfam PF01160 Entrez Gene 5173 Kegg hsa:5173

References

  1. UniProt :accession P01213
  2. The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 486