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prenyltransferase
Specific
farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E)-farnesyl diphosphate synthase; dimethylallyltranstransferase; farnesyl diphosphate synthase; geranyltranstransferase (FDPS, FPS, KIAA1293)
farnesyltransferase
geranylgeranyl pyrophosphate synthase; GGPP synthase; GGPPSase; geranylgeranyl diphosphate synthase; geranyltranstransferase (GGPS1)
geranylgeranyltransferase (GGTase)
geranylgeranyltransferase-2 (GGTase-2, rab GGTase)
p-hydroxybenzoate-polyprenyltransferase, mitochondrial (PHB:polyprenyltransferase, hCOQ2, COQ2, CL640)
squalene synthetase (farnesyl-diphosphate farnesyltransferase, FDFT1, SQS)
General
multisubunit protein
transferase
Properties
COMPARTMENT: cytoplasm
MOTIF: active site
SUBUNITS: prenyl transferase-alpha
MOTIF: proline-rich region
SITE: 22-31
MOTIF: proline residue (SEVERAL)
PFTA {112-146}
PFTA {147-180}
PFTA {181-215}
PFTA {216-249}
PFTA {255-289}
prenyl transferase-beta
MOTIF: binding site
FOR-BINDING-OF: ras superfamily protein
References
- Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS.
Inhibition of purified p21ras farnesyl:protein transferase by
Cys-AAX tetrapeptides.
Cell. 1990 Jul 13;62(1):81-8.
PMID: 2194674
- Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL.
Protein farnesyltransferase and geranylgeranyltransferase share
a common alpha subunit.
Cell. 1991 May 3;65(3):429-34.
PMID: 2018975
Components
CAAX farnesyltransferase alpha subunit (FNTA, RAS proteins prenyltransferase-alpha)
prenyltransferase-beta