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preimplantation genetic diagnosis (PGD)
Genetic analysis on embryos after in vitro fertilization, prior to implantation into the uterus of the maternal host.
Indications:
1) selection of healthy embryos for high-risk couples
2) HLA matching to preselection of embryos that offer the potential of bone marrow transplantation*
* Example (of Fanconi's anemia)
1) a couple has a child with a severe genetic disease, i.e. Fanconi's anemia
2) PGD may be used to select an in vitro fertilized homozygous normal or heterozygous carrier that is HLA matched with the affected sibling
3) at birth, cord blood is collected from the in-vitro fertilized newborn
4) the cord blood is transplanted into the affected sibling which results in successful hematopoietic reconstitution
General
special chemistry test
References
- Journal Watch 21(14);117, 2001
- Preimplantation diagnosis for Fanconi anemia combined with
HLA matching.
- Verlinsky Y, Rechitsky S, Schoolcraft W, Strom C, Kuliev A.
JAMA 285:3130, 2001
- Damewood MD
Ethical implications of a new application of preimplantation diagnosis
JAMA 285:3143, 2001
PMID: 11427146