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prefrailty
Term found in GRS9 [1]
Etiology:
- risk factors same as frailty
* prefrail persons 50% more likely with metabolic syndrome than normal age-matched controls [1]
Epidemiology:
- prevalence 25-50% in persons > 65 years of age
Clinical manifestations:
- most common
- muscle weakness
- slow gait speed
- exhaustion less common
Related
frailty
General
syndrome
References
- Geriatric Review Syllabus, 9th edition (GRS9)
Medinal-Walpole A, Pacala JT, Porter JF (eds)
American Geriatrics Society, 2016
- Barzilay JI, Blaum C, Moore T et al
Insulin resistance and inflammation as precursors of frailty:
the Cardiovascular Health Study.
Arch Intern Med. 2007 Apr 9;167(7):635-41.
PMID: 17420420
- Danon-Hersch N, Rodondi N, Spagnoli J, Santos-Eggimann B.
Prefrailty and chronic morbidity in the youngest old: an
insight from the Lausanne cohort Lc65+.
J Am Geriatr Soc. 2012 Sep;60(9):1687-94.
PMID: 22906300
- Fernandez-Garrido J, Ruiz-Ros V, Buigues C et al
Clinical features of prefrail older individuals and emerging
peripheral biomarkers: a systematic review.
Arch Gerontol Geriatr. 2014 Jul-Aug;59(1):7-17.
PMID: 24679669