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PrecivityAD2 blood test algorithm; amyloid probability score 2 (APS2); plasma ptau217/total tau + amyloid-beta-42/amyloid-beta-40 in plasma

Indications: - diagnostic workup for potential Alzheimer's disease - diagnostic accuracy of 91% [1] Procedure: - plasma ptau217/total tau + plasma amyloid-beta-42/40 - no difference in diagnostic accuracy between APS2 & plasma ptau217 alone [1] Method: - mass spectrometry Notes: - clinically usedful [2]

General

analyte ratio algorithm laboratory evaluation of Alzheimer's disease

References

  1. George J Alzheimer's Blood Test More Accurate Than Primary Care or Specialist Diagnoses. Testing recommended only for patients with cognitive impairment, not the "worried well" MedPage Today, July 28, 2024 https://www.medpagetoday.com/meetingcoverage/aaic/111274 - Palmqvist S, Tideman P, Mattsson-Carlgren N et al Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care. JAMA. 2024 Jul 28:e2413855. PMID: 39068545 https://jamanetwork.com/journals/jama/fullarticle/2821669
  2. Monane M, Maraganore DM, Carlile RM et al Clinical Utility of an Alzheimer's Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study. Diagnostics (Basel). 2025 Jan 13;15(2):167. PMID: 39857051 PMCID: PMC11764142 Free PMC article. https://www.mdpi.com/2075-4418/15/2/167

Components

amyloid-beta peptide 40/42 in plasma microtubule-associated protein tau in plasma phosphorylated tau(Thr)217 in plasma (plasma ptau217)