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PrecivityAD2 blood test algorithm; amyloid probability score 2 (APS2); plasma ptau217/total tau + amyloid-beta-42/amyloid-beta-40 in plasma
Indications:
- diagnostic workup for potential Alzheimer's disease
- diagnostic accuracy of 91% [1]
Procedure:
- plasma ptau217/total tau + plasma amyloid-beta-42/40
- no difference in diagnostic accuracy between APS2 & plasma ptau217 alone [1]
Method:
- mass spectrometry
Notes:
- clinically usedful [2]
General
analyte ratio
algorithm
laboratory evaluation of Alzheimer's disease
References
- George J
Alzheimer's Blood Test More Accurate Than Primary Care or Specialist Diagnoses.
Testing recommended only for patients with cognitive impairment, not the "worried well"
MedPage Today, July 28, 2024
https://www.medpagetoday.com/meetingcoverage/aaic/111274
- Palmqvist S, Tideman P, Mattsson-Carlgren N et al
Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care.
JAMA. 2024 Jul 28:e2413855.
PMID: 39068545
https://jamanetwork.com/journals/jama/fullarticle/2821669
- Monane M, Maraganore DM, Carlile RM et al
Clinical Utility of an Alzheimer's Disease Blood Test Among Cognitively Impaired
Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician
Survey Study.
Diagnostics (Basel). 2025 Jan 13;15(2):167.
PMID: 39857051 PMCID: PMC11764142 Free PMC article.
https://www.mdpi.com/2075-4418/15/2/167
Components
amyloid-beta peptide 40/42 in plasma
microtubule-associated protein tau in plasma
phosphorylated tau(Thr)217 in plasma (plasma ptau217)