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pre-replication complex
Function:
- binds to origin of DNA replication & with help from two further protein factors (Cdc6 & Cdt1), load the minichromosome maintenance protein complex
- once assembled, the complex unwinds, & begins to copy DNA
Structure:
- formed from: origin of replication complex, Cdc6, Cdt1 & minichromosome maintenance protein complex
Related
nucleoplasm (GO:0005654)
origin of replication
General
DNA-binding protein
molecular complex
Properties
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SUBUNITS: origin of replication complex (origin recognition complex, ORC)
MOTIF: DNA-binding motif
cell division control protein 6 homolog
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S45}
Ser phosphorylation site {S54}
Thr phosphorylation site {T166}
ATP-binding site
NAME: ATP-binding site
SITE: 202-209
DNA replication factor Cdt1
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T29}
Ser phosphorylation site {S31}
Cyclin-binding {68-70}
GMNN interaction {150-190}
Ser phosphorylation site {S318}
Ser phosphorylation site {S372}
Ser phosphorylation site {S394}
minichromosome maintenance (Mcm) protein
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
active site
MOTIF: P-loop
FOR-BINDING-OF: adenosine triphosphate
References
- WikiPedia: Origin of Replication
http://en.wikipedia.org/wiki/Origin_of_replication
Components
cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6 (CDC6, CDC18L)
DNA replication factor Cdt1; double parked homolog; DUP (CDT1)
minichromosome maintenance (Mcm) protein
origin of replication complex (origin recognition complex, ORC)