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proline-rich protein PRCC; papillary renal cell carcinoma translocation-associated gene protein (PRCC TPRC)
Expression: ubiquitous in fetal & adult tissues
Pathology:
- chromosomal translocation t(X;1)(p11.2;q21.2) involving PRCC with TFE3 may be a cause of papillary renal cell carcinoma
General
phosphoprotein
proline-rich protein
proto oncogene protein
Properties
SIZE: entity length = 491 aa
MW = 52 kD
MOTIF: Ser phosphorylation site {S8}
Ser phosphorylation site {S9}
Ser phosphorylation site {S12}
glutamate-rich region {18-25}
MOTIF: glutamate residue (SEVERAL)
proline-rich region
SITE: 52-55
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 79-84
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 91-94
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S157}
Ser phosphorylation site {S159}
Ser phosphorylation site {S218}
threonine-rich region {235-239}
MOTIF: threonine residue (SEVERAL)
Thr phosphorylation site {T239}
Ser phosphorylation site {S241}
Ser phosphorylation site {S243}
Ser phosphorylation site {S267}
Database Correlations
OMIM correlations
UniProt Q92733
Entrez Gene 5546
Kegg hsa:5546
References
- UniProt :accession Q92733
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PRCCID69.html
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/PRCC