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basic salivary proline-rich protein 4; salivary proline-rich protein Po; parotid o protein; salivary proline-rich protein II-1, [Contains: protein N1; glycosylated protein A; Peptide P-D] (PRB4)
Function:
- proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine
- the endoprotease may be of microbial origin
- pyroglutamate formation found on at least Gln-46, Gln-48, Gln-67, Gln-88; Gln-90; Gln-193; Gln-288 Gln-214 & Gln-295, preferentially in diabetic, & head & neck cancer patients
Structure:
- N-glycosylated
Compartment: secreted
Polymorphism:
- number of repeats is polymorphic & varies among different alleles
- allele S (short), allele M (medium) & allele L (long) contain 6, 7 & 9 tandem repeats respectively
General
salivary proline-rich protein
Properties
SIZE: entity length = 310 aa
MW = 31 kD
COMPARTMENT: saliva
MOTIF: signal sequence {1-16}
domain {35-234}
MOTIF: consensus repeat {35-55}
consensus repeat {56-76}
N-glycosylation site {N66}
consensus repeat {77-97}
N-glycosylation site {N87}
consensus repeat {98-118}
N-glycosylation site {N108}
consensus repeat {119-139}
consensus repeat {140-160}
N-glycosylation site {N150}
consensus repeat {161-181}
N-glycosylation site {N171}
consensus repeat {182-202}
N-glycosylation site {N192}
consensus repeat {203-223}
N-glycosylation site {N213}
consensus repeat {224-234}
N-glycosylation site {N234}
Database Correlations
OMIM 180990
UniProt P10163
Entrez Gene 5545
Kegg hsa:5545
References
- UniProt :accession P10163
- Singapore human mutation & polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PRB4