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prazepam (Centrax)
Tradename: Centrax. DEA-controlled substance: class 4.
Dosage:
- 10 mg PO TID [1].
- 20-60 mg/24 hours in divided doses or QHS [2].
Tabs: 5, 10, 20 mg.
Pharmacokinetics:
-> near complete 1st pass dealkylation in liver to active metabolite desmethyldiazepam
Adverse effects:
1) confusion
2) ataxia
3) excitement
4) agitation
5) transient hypotension
6) vertigo
7) drug fever
8) dyspepsia
9) leukopenia
10) hepatotoxicity
Drug interactions:
1) carbamazepine may increase hepatic metabolism
2) cimetidine, estrogens, disulfiram, erythromycin may inhibit hepatic metabolism
Laboratory:
1) specimen: serum, plasma (EDTA)
2) methods: HPLC, GLC
Interactions
drug interactions
drug adverse effects (more general classes)
General
benzodiazepine
Properties
MISC-INFO: elimination route LIVER
KIDNEY
1/2life 36-200 HOURS
therapeutic-range 0.12-1.0 UG/ML
protein-binding 97%
pregnancy-category D
safety in lactation -
Database Correlations
PUBCHEM cid=4890
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
- Manual of Medical Therapeutics, 28th ed, Ewald &
McKenzie (eds), Little, Brown & Co, Boston, 1995,
pg 7
- Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed,
WB Saunders, Philadelpha 1995