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PRA1 family protein 2 (PRAF2)
Function:
- role in ER/Golgi transport & vesicular traffic
- interacts with CCR5
Structure: belongs to the PRA1 family
Compartment: membrane
Expression:
- strong expression in the brain, small intestine, lung, spleen, & pancreas
Pathology:
- breast cancer, colon cancer, lung cancer, ovarian cancer, with weaker expression in normal tissues
General
transmembrane 4 protein
Properties
SIZE: MW = 19 kD
entity length = 178 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-41}
transmembrane domain {42-62}
exoplasmic loop {63-64}
transmembrane domain {65-85}
cytoplasmic loop {86-96}
transmembrane domain {97-119}
exoplasmic loop {120-122}
transmembrane domain {123-140}
cytoplasmic domain {141-178}
Database Correlations
UniProt O60831
Pfam PF03208
References
UniProt :accession O60831