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cyclin D1 (parathyroid adenomatosis-1 [PRAD1] protein or bcl-1 proto-oncogene protein, CCND1, BCL1)

Function: - essential for the control of the cell cycle at the G1/S (start) transition - interacts with the CDK4 & CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex; the cyclin subunit imparts substrate specificity to the complex Structure: belongs to the cyclin family. cyclin D subfamily Pathology: - chromosomal translocation t(11;14)(q13;q32) involving CCND1 with immunoglobulin gene regions may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma; activation of CCND1 may be oncogenic by directly altering progression through the cell cycle - chromosomal translocation t(11;11)(q13;p15) involving CCND1 with the parathyroid hormone (PTH) enhancer may be a cause of parathyroid adenomas [MIM:168461] - chromosomal translocation t(11;14)(q13;q32) involving CCND1 with the IgH locus may be a cause of multiple myeloma - overexpression in mantle-cell lymphoma Laboratory: - translocation t(11;14)(q13;q32)(CCND1,IGH) in blood/tissue - CCND1 gene duplication - CCND1 gene mutation - CCND1 gene rearrangement - BCL1/cyclin D1 Ag in tissue

Related

CDK6/cyclin D complex cell cycle parathyroid adenomatosis [PRAD]-1 gene, CCND1 or bcl-1

General

cyclin D proto oncogene protein

Properties

SIZE: MW = 36 kD entity length = 295 aa COMPARTMENT: cytoplasm CELL: fibroblast MOTIF: ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin PEST region cyclin box FOR-BINDING-OF: cyclin-dependent kinase LXC motif FOR-BINDING-OF: retinoblastoma-associated protein glutamate-rich region MOTIF: glutamate residue (9)

References

  1. Motokura T et al A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. 1991 Apr 11;350(6318):512-5. PMID: 1826542
  2. Ross CA et al Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. Trends Neurosci. 1993 Jul;16(7):254-60. Review. PMID: 7689767
  3. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/BCL1.html
  4. The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CCND1
  5. UniProt :accession P24385

Component-of

CDK4/cyclin D1 complex

Databases & Figures

OMIM correlations UniProt P24385 PFAM correlations Entrez Gene 595 Kegg hsa:595 RTK -> PI-3-kinase -> Akt -> ...