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phosphoprotein phosphatase-5 catalytic subunit (protein phosphatase T, PP-T, PPT, PPP5C, PPP5)
Function:
- may play a role in the regulation of RNA biogenesis &/or mitosis
- in vitro, dephosphorylates Ser of skeletal muscle phosphorylase & histone H1
- interacts with CDC16 & CDC27
phosphoprotein + H2O a protein + phosphate
Cofactor:
- binds 1 iron ion per subunit (putative)
- binds 1 Mn+2 per subunit (putative)
Structure:
- belongs to the PPP phosphatase family, PP-5 (PP-T) subfamily
- contains 3 TPR repeats
Compartment:
- nucleus, cytoplasm
- predominantly nuclear, but also present in the cytoplasm
Expression: ubiquitous
General
serine/threonine phosphatase
Properties
SIZE: entity length = 499 aa
MW = 57 kD
COMPARTMENT: cytoplasm
cell nucleus
STATE: active state
MOTIF: tetratricopeptide repeat {28-61}
tetratricopeptide repeat {62-95}
tetratricopeptide repeat {96-129}
active site
SITE: 184-499
MOTIF: Iron [Fe]-binding site
SITE: 242-242
Iron [Fe]-binding site
SITE: 244-244
Iron [Fe]-binding site
SITE: 271-271
manganese [Mn]-binding site
SITE: 271-271
manganese [Mn]-binding site
SITE: 303-303
histidine residue {H304}
manganese [Mn]-binding site
SITE: 352-352
manganese [Mn]-binding site
SITE: 427-427
Database Correlations
OMIM 600658
UniProt P53041
PFAM correlations
KEGG correlations
ENZYME 3.1.3.16
References
UniProt :accession P53041