protein phosphatase-1 regulatory subunit 9B (neurabin-2, spinophilin, PPP1R9B)

Function: 1) scaffold protein (putative) 2) modulates excitatory synaptic transmission & dendritic spine morphology 3) binds to actin filaments (F-actin) along sides 4) links actin cytoskeleton to the plasma membrane at the synaptic junction (putative) 5) G-protein coupled receptor signaling (putative) a) dopamine D2 receptors b) alpha-adrenergic receptors 6) interacts with F-actin, PPP1CA, neurabin-1, TGN38, dopamine-D2-receptor, RGS1, RGS2, RGS4, RGS19, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1, TIAM1 Compartment: - cytoplasm, nucleus - enriched at synapse & cadherin-based cell-cell adhesion sites - enriched in the post-synaptic density apposed to exitatory synapses - colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells & in dendritic spines

Properties

INHIBITS: phosphatase SIZE: MW = 89 kD entity length = 815 aa MOTIF: binding site SITE: 1-154 FOR-BINDING-OF: actin MOTIF: Ser phosphorylation site {S15} Ser phosphorylation site {S17} Ser phosphorylation site {S94} binding site SITE: 100-369 FOR-BINDING-OF: dopamine D2 receptor MOTIF: Ser phosphorylation site {S100} Ser phosphorylation site {S116} binding site SITE: 163-281 FOR-BINDING-OF: actin binding site SITE: 167-253 FOR-BINDING-OF: alpha-2A adrenergic receptor alpha-2B adrenergic receptor alpha-2C adrenergic receptor Ser phosphorylation site {S203} proline-rich region SITE: 251-259 MOTIF: proline residue (SEVERAL) binding site SITE: 415-492 FOR-BINDING-OF: phosphatase-1 binding site SITE: 478-523 FOR-BINDING-OF: regulator of G-protein signaling 2 PDZ domain NAME: PDZ domain SITE: 494-582 binding site SITE: 593-814 FOR-BINDING-OF: trans GOLGI network protein (TGN38) MOTIF: coiled coil {593-614} coiled coil {663-814}

Database Correlations

OMIM 603325 UniProt Q96SB3 Pfam PF00595 Entrez Gene 84687

References

UniProt :accession Q96SB3