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protein phosphatase 1 regulatory subunit 3D; protein phosphatase 1 regulatory subunit 6; PP1 subunit R6; protein phosphatase 1-binding subunit R6 (PPP1R3D, PPP1R6)
Function:
- seems to act as a glycogen-targeting subunit for PP1
- interacts with PPP1CC catalytic subunit of PP1, & associates with glycogen
Structure:
- the CBM21 domain is known to be involved in the localization to glycogen & is characteristic of some regulatory subunit of phosphatase complexes
- contains 1 CBM21 (carbohydrate binding type-21) domain
Expression:
- expressed in all tissue tested
- high expression in skeletal muscle & heart
General
protein phosphatase-1 regulatory subunit
Properties
INHIBITS: phosphatase
SIZE: entity length = 299 aa
MW = 33 kD
MOTIF: Ser phosphorylation site {S23}
Ser phosphorylation site {S25}
Ser phosphorylation site {S28}
Ser phosphorylation site {S74}
Ser phosphorylation site {S77}
Ser phosphorylation site {S78}
PP1-binding {101-104}
CBM21 {169-278}
Database Correlations
OMIM 603326
UniProt O95685
Pfam PF03370
Entrez Gene 5509
Kegg hsa:5509
References
UniProt :accession O95685