protein phosphatase-1 regulatory subunit 3C (protein phosphatase 1 regulatory subunit 5, R5, protein targeting to glycogen, PTG, PPP1R3C, PPP1R5)

Function: - glycogen-targeting subunit for PP1 & regulates its activity - activates glycogen synthase - diminishes glycogen phosphorylase activity - limits glycogen breakdown - increases basal & insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types - interacts with PPP1CC catalytic subunit of PP1 & associates with glycogen - forms complexes with glycogen phosphorylase, glycogen synthase & phosphorylase kinase which is necessary for its regulation of PP1 activity - interacts with EPM2A/laforin Structure: - contains 1 CBM21 domain (carbohydrate binding type-21) - N-terminal region is required for binding to PP1 - central region is required for binding to glycogen - C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase & phosphorylase kinase

Properties

INHIBITS: phosphatase SIZE: MW = 36 kD entity length = 317 aa MOTIF: EPM2A interaction {141-263} MOTIF: CBM21 {149-257}

Database Correlations

OMIM 602999 UniProt Q9UQK1 LOCUS-LINK correlations

References

UniProt :accession Q9UQK1