protein phosphatase 1 regulatory subunit 15B (PPP1R15B)

Function: - maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1 - part of a complex containing PPP1R15B, PP1 & NCK1/2 - interacts with PP1 Structure: belongs to the PPP1R15 family Notes: - phosphatase activity of the PPP1R15B-PP1 complex toward EIF2S1 is specifically inhibited by salubrinal, a drug that protects cells from endoplasmic reticulum stress

Properties

INHIBITS: phosphatase SIZE: entity length = 713 aa MW = 79 kD MOTIF: S/T-phosphate allosteric site

Database Correlations

OMIM 613257 UniProt Q5SWA1 PFAM correlations Entrez Gene 84919 Kegg hsa:84919

References

UniProt :accession Q5SWA1