RelA-associated inhibitor (inhibitor of ASPP protein, protein iASPP, PPP1R13B-like protein, NFkB-interacting protein 1, PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI)

Function: 1) role in regulation of apoptosis & transcription via interaction with NF-kappa-B & p53/TP53 proteins 2) blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B & SP1 3) inhibits p53/TP53 function via preventing association of p53/TP53 & ASPP1 or ASPP2, thus suppresses apoptosis (putative) 4) interacts with RELA NF-kappa-B subunit & with SP1 via its C-terminus Structure: - belongs to the ASPP family - contains 2 ANK repeats contains 1 SH3 domain Compartment: - isoform 1: cytoplasm, nucleus (predominantly cytoplasmic) - N-terminal region of isoform 1 is required for cytoplasmic localization - isoform 2: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in heart, placenta, prostate > brain, liver, skeletal muscle, testis, peripheral blood leukocyte Pathology: - defects in PPP1R13L may be a cause of breast cancers - overexpressed in many patients with breast cancer & expressing a wild-type p53/TP53 protein

Properties

SIZE: MW = 89 kD entity length = 828 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 54-602 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S110} Ser phosphorylation site {S113} Ser phosphorylation site {S183} Ser phosphorylation site {S187} glutamine-rich region {407-444} MOTIF: glutamine residue (SEVERAL) ankyrin repeat NAME: ankyrin repeat SITE: 659-691 ankyrin repeat NAME: ankyrin repeat SITE: 692-724 src homology 3 [SH3] domain SITE: 758-820

Database Correlations

OMIM 607463 UniProt Q8WUF5 PFAM correlations

References

UniProt :accession Q8WUF5