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protein phosphatase 1 regulatory subunit 12C (protein phosphatase 1 myosin-binding subunit of 85 kD, protein phosphatase 1 myosin- binding subunit p85, PPP1R12C, MBS85)
Function:
- regulates myosin phosphatase activity
- interacts via its N-terminus with PPP1CB
- interacts with IL16
- interacts with the coiled-coil domain of MRIP
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: contains 4 ANK repeats
Compartment:
- cytoplasm, along actomyosin filaments & stress fibers
Alternative splicing: named isoforms=4
Expression:
- ubiquitously expressed
- highly expressed in heart
General
ankyrin repeat domain protein (ANKRD)
protein phosphatase-1 regulatory subunit
phosphoprotein
Properties
COMPARTMENT: cytoplasm
INHIBITS: phosphatase
SIZE: entity length = 782 aa
MW = 85 kD
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 100-129
ankyrin repeat
NAME: ankyrin repeat
SITE: 133-162
ankyrin repeat
NAME: ankyrin repeat
SITE: 226-255
ankyrin repeat
NAME: ankyrin repeat
SITE: 259-288
coiled coil {297-329}
Ser phosphorylation site {S427}
proline-rich region
SITE: 473-523
MOTIF: proline residue (SEVERAL)
Thr phosphorylation site {T560}
coiled coil {681-782}
Database Correlations
UniProt Q9BZL4
Pfam PF00023
Entrez Gene 54776
Kegg hsa:5477
References
UniProt :accession Q9BZL4