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protein phosphatase 1 regulatory subunit 12B; myosin phosphatase-targeting subunit 2; myosin phosphatase target subunit 2 (PPP1R12B, MYPT2)
Function:
- regulates myosin phosphatase activity
- augments Ca+2 sensitivity of the contractile apparatus
- isoform 3 & isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself
- binds IL16
Structure: contains 5 ANK repeats
Compartment:
- cytoplasm
- along actomyosin filaments & stress fibers
Alternative splicing:
- named isoforms=4
- alternative promoter usage
Expression:
- detected in skeletal muscle, fetal & adult heart, brain, placenta, kidney, spleen, thymus, pancreas & lung
- isoform 3 & isoform 4 are heart specific
General
ankyrin repeat domain protein (ANKRD)
protein phosphatase-1 regulatory subunit
phosphoprotein
Properties
COMPARTMENT: cytoplasm
INHIBITS: phosphatase
SIZE: entity length = 982 aa
MW = 110 kD
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 57-86
ankyrin repeat
NAME: ankyrin repeat
SITE: 90-119
ankyrin repeat
NAME: ankyrin repeat
SITE: 123-152
ankyrin repeat
NAME: ankyrin repeat
SITE: 216-245
ankyrin repeat
NAME: ankyrin repeat
SITE: 249-278
glutamate-rich region {336-379}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S839}
Ser phosphorylation site {S947}
Database Correlations
OMIM 603768
UniProt O60237
Pfam PF00023
Entrez Gene 4660
Kegg hsa:4660
References
UniProt :accession O60237