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serine/threonine protein phosphatase PP1-gamma catalytic subunit; PP-1G; protein phosphatase 1C catalytic subunit (PPP1CC)

Function: - catalytic subunit of protein phosphatase 1 (PP1) - component of the PTW/PP1 phosphatase complex - component of the MLL5-L complex - part of a complex containing PPP1R15B, PP1 & NCK1/2 - interacts with cyanobacterial toxin microcystin; disulfide-linked - interacts with PPP1R3B & PPP1R7 - isoform gamma-2 interacts with SPZ1 (putative) - interacts with CDCA2 - interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, - dephosphorylates IKAROS, stabilizes it & prevents it from degradation (putative) - interacts with NOM1 & PPP1R8 Cofactor: - binds 1 iron ion per subunit - binds 1 Mn+2 per subunit a phosphoprotein + H2O = a protein + phosphate Structure: - belongs to the PPP phosphatase family, PP-1 subfamily Compartment: - cytoplasm, nucleus, nucleolus, nucleoplasm, nucleus speckle - chromosome, centromere, kinetochore, cleavage furrow, midbody - colocalizes with SPZ1 in the nucleus (putative) - rapidly exchanges between the nucleolar, nucleoplasmic & cytoplasmic compartments - highly mobile in cells & can be relocalized through interaction with targeting subunits - in the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles - shows a dynamic targeting to specific sites throughout the cell cycle - highly concentrated in nucleoli of interphase cells & localizes at kinetochores early in mitosis - relocalization to chromosome-containing regions occurs at the transition from early to late anaphase - accumulates at the cleavage furrow & midbody by telophase Alternative splicing: named isoforms=2; gamma-1, gamma-2 Notes: - microcystin toxin is bound to Cys-273 through a thioether bond

Related

MLL5-L complex phosphatase-1 (PP1) PTW/PP1 phosphatase complex

General

phosphatase-1 catalytic subunit

Properties

SIZE: entity length = 323 aa MW = 37 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Iron [Fe]-binding site SITE: 64-64 Iron [Fe]-binding site SITE: 66-66 Iron [Fe]-binding site SITE: 92-92 MOTIF: manganese [Mn]-binding site SITE: 92-92 manganese [Mn]-binding site SITE: 124-124 histidine residue {H125} manganese [Mn]-binding site SITE: 173-173 manganese [Mn]-binding site SITE: 248-248 cysteine residue {273} Thr phosphorylation site {T307} STATE: active state

Database Correlations

OMIM 176914 UniProt P36873 Pfam PF00149 Entrez Gene 5501 Kegg hsa:5501 ENZYME 3.1.3.16

References

  1. UniProt :accession P36873
  2. Protein Spotlight; Note: the things we forget - Issue 32 of march 2003 http://www.expasy.org/spotlight/back_issues/sptlt032.shtml

Component-of

MLL5-L complex