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serine/threonine protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Function: - one of 3 alternate catalytic subunits of protein phosphatase 1 (PP1) - component of the PTW/PP1 phosphatase complex - component of the MLL5-L complex - part of a complex containing PPP1R15B, PP1 & NCK1/2 (putative) - interacts with PPP1R7 & PPP1R12C - interacts with PPP1R8 Cofactor: - binds 1 iron ion per subunit (putative) - binds 1 Mn+2 per subunit (putative) Inhibition: - inhibited by the toxins okadaic acid, tautomycin & microcystin Leu-Arg (putative) phosphoprotein + H2O = a protein + phosphate [myosin light-chain] phosphate + H2O = [myosin light-chain] + phosphate Structure: - belongs to the PPP phosphatase family, PP-1 subfamily Compartment: - cytoplasm, nucleus, nucleoplasm, nucleolus - highly mobile in cells & can be relocalized through interaction with targeting subunits - in the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles

Related

MLL5-L complex phosphatase-1 (PP1) PTW/PP1 phosphatase complex

General

phosphatase-1 catalytic subunit

Properties

SIZE: entity length = 327 aa MW = 37 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S41} Ser phosphorylation site {S47} Iron [Fe]-binding site SITE: 63-63 Iron [Fe]-binding site SITE: 65-65 Iron [Fe]-binding site SITE: 91-91 MOTIF: manganese [Mn]-binding site SITE: 91-91 manganese [Mn]-binding site SITE: 123-123 histidine residue {H124} manganese [Mn]-binding site SITE: 172-172 manganese [Mn]-binding site SITE: 247-247 Tyr phosphorylation site {Y306} Thr phosphorylation site {T316} STATE: active state

Database Correlations

OMIM 600590 UniProt P62140 Pfam PF00149 Entrez Gene 5500 KEGG correlations ENZYME correlations

References

  1. UniProt :accession P62140
  2. Protein Spotlight; Note: the things we forget - Issue 32 of march 2003 http://www.expasy.org/spotlight/back_issues/sptlt032.shtml

Component-of

MLL5-L complex