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protein phosphatase 1F; Ca+2/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; partner of PIX 2; protein fem-2 homolog; hFem-2 (PPM1F, KIAA0015, POPX2)
Function:
- dephosphorylates & concomitantly deactivates
a) CaM-kinase 2 activated upon autophosphorylation
b) CaM-kinase 1 & CaM-kinase 4 activated upon phosphorylation by CaM-kinase kinase
- promotes apoptosis
- associates with FEM1B
Cofactor:
- binds 2 Mg+2 or Mn+2 per subunit
Structure: belongs to the PP2C family
General
metalloprotein
phosphoprotein phosphatase
Properties
SIZE: entity length = 454 aa
MW = 50 kD
MOTIF: glutamate-rich region {101-107}
MOTIF: glutamate residue (SEVERAL)
manganese [Mn]-binding site
SITE: 198-198
manganese [Mn]-binding site
SITE: 199-199
active site
manganese [Mn]-binding site
SITE: 360-360
manganese [Mn]-binding site
SITE: 404-404
STATE: active state
Database Correlations
UniProt P49593
Pfam PF00481
Entrez Gene 9647
Kegg hsa:9647
ENZYME 3.1.3.16
References
UniProt :accession P49593