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peptidylprolyl cis-trans isomerase A-like 4B (PPIase A-like 4B, chromosome 1-amplified sequence 2, COAS-2, cyclophilin homolog overexpressed in liver cancer, PPIAL4B COAS2)
Function:
- PPIases accelerate the folding of proteins
- catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides (putative)
peptidylproline (omega=180) peptidylproline (omega=0)
Structure:
- belongs to the cyclophilin-type PPIase family, PPIase A subfamily
- contains 1 PPIase cyclophilin-type domain
Compartment: cytoplasm (putative)
Expression:
- highly expressed in brain, ovary & mammary gland
- moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine & spleen
- weakly expressed in skeletal muscle, liver & stomach
Pathology:
- expressed in pleomorphic & undifferentiated liposarcomas, osteosarcomas & breast carcinomas
Genetics:
- one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1
- expression studies do not distinguish between PPIAL4B & PPIAL4 [2]
General
peptidyl-prolyl cis/trans isomerase (PPIase) or rotamase
Properties
SIZE: entity length = 164 aa
MW = 18 kD
COMPARTMENT: cytoplasm
MOTIF: active site
SITE: 7-163
Database Correlations
OMIM 608608
UniProt Q9Y536
Pfam PF00160
KEGG correlations
ENZYME 5.2.1.8
References
- UniProt :accession Q9Y536
- PMID: 11948409