peptidylprolyl cis-trans isomerase A-like 4; PPIase A-like 4; chromosome 1-amplified sequence 2; COAS-2 (PPIAL4, COAS2, PPIAL4A)

Function: - PPIases accelerate the folding of proteins - catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (putative) peptidylproline (omega=180) peptidylproline (omega=0) Structure: - belongs to the cyclophilin-type PPIase family, PPIase A subfamily - contains 1 PPIase cyclophilin-type domain Compartment: cytoplasm (putative) Expression: - expressed in brain, ovary & mammary gland > lung, salivary gland, kidney, skin, adipose tissue, intestine & spleen > skeletal muscle, liver & stomach Pathology: - expressed in pleomorphic & undifferentiated liposarcomas, osteosarcomas & breast carcinomas Genetics: - gene is 1 of 7 related genes or pseudogenes found in a cluster on chromosome 1, thought to result from gene duplication

Properties

SIZE: entity length = 164 aa MW = 18 kD COMPARTMENT: cytoplasm MOTIF: active site SITE: 7-163

Database Correlations

OMIM 608608 Pfam PF00160 KEGG correlations

References

UniProt :accession A2BFH1 withdrawn