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periphilin-1 (gastric cancer antigen Ga50, PPHLN1)
Function:
1) role in epithelial differentiation
2) contributes to epidermal integrity & barrier formation
3) interacts with PPL
4) substrate of transglutaminase (in vitro)
Structure: homodimer
Compartment:
- nucleus, cytoplasm
- in undifferentiated keratinocytes, expressed in speckle-type nuclear granules & at nuclear membrane
- in differentiated keratinocytes, colocalized with periplakin at the cell periphery & at cell-cell junctions
Alternative splicing: named isoforms=8
Expression: ubiquitous
General
phosphoprotein
Properties
SIZE: MW = 53 kD
entity length = 458 aa
COMPARTMENT: cytoplasm
nuclear membrane
MOTIF: nuclear translocation signal {103-109}
serine-rich region {140-215}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S205}
Database Correlations
OMIM 608150
UniProt Q8NEY8
References
UniProt :accession Q8NEY8