liprin-alpha-4; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4; PTPRF-interacting protein alpha-4 (PPFIA4 KIAA0897)

Function: - may regulate the disassembly of focal adhesions - may localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment & their association with substrates - forms homodimers & heterodimers with liprins-alpha & liprins-beta - interacts with the second PTPase domain of PTPRD, PTPRF & PTPRS - binds RIMS1, RIMS2, GIT1, KIF1A & GRIP1 Structure: - the N-terminal coiled coil regions mediate homodimerization preferentially & heterodimerization type alpha/alpha - the C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta & interaction with PTPRD, PTPRF & PTPRS (putative) - belongs to the liprin family, liprin-alpha subfamily - contains 3 SAM (sterile alpha motif) domains Compartment: - cytoplasm (putative). cell surface - colocalizes with PTPRF at the cytoplasmic face of the plasma membrane Alternative splicing: named isoforms=2 Expression: - expressed only in the heart, brain, & skeletal muscle

Properties

SIZE: entity length = 701 aa MW = 78 kD COMPARTMENT: cytoplasm MOTIF: coiled coil {82-128} sterile alpha motif NAME: sterile alpha motif SITE: 345-411 sterile alpha motif NAME: sterile alpha motif SITE: 460-524 coiled coil {518-547} SAM 3 {548-617}

Database Correlations

OMIM 603145 UniProt O75335 PFAM correlations Entrez Gene 8497 Kegg hsa:8497

References

UniProt :accession O75335