liprin-alpha-3; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3; PTPRF-interacting protein alpha-3 (PPFIA3, KIAA0654)

Function: - may regulate the disassembly of focal adhesions - may localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment & their association with substrates - forms homodimers & heterodimers with liprins-alpha & liprins-beta - interacts with the second PTPase domain of PTPRD, PTPRF & PTPRS - binds RIMS1, RIMS2, RIMS3 & RIMS4 Structure: - the N-terminal coiled coil regions mediate homodimerization preferentially & heterodimerization type alpha/alpha - the C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta & interaction with PTPRD, PTPRF & PTPRS - belongs to the liprin family, liprin-alpha subfamily - contains 3 SAM (sterile alpha motif) domains Compartment: - cytoplasm (putative), cell surface - colocalizes with PTPRF at the at the cytoplasmic face of the plasma membrane Alternative splicing: - named isoforms=2 - may be due to an exon skipping Expression: expressed only in brain

Properties

SIZE: entity length = 1194 aa MW = 133 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S17} coiled coil {26-133} coiled coil {161-501} MOTIF: Ser phosphorylation site {S207} Ser phosphorylation site {S508} coiled coil {596-644} Ser phosphorylation site {S645} Ser phosphorylation site {S683} Thr phosphorylation site {T714} Thr phosphorylation site {T718} sterile alpha motif NAME: sterile alpha motif SITE: 838-904 sterile alpha motif NAME: sterile alpha motif SITE: 953-1017 coiled coil {1014-1040} SAM 3 {1041-1110} Ser phosphorylation site {S1164}

Database Correlations

OMIM 603144 UniProt O75145 PFAM correlations Entrez Gene 8541 Kegg hsa:8541

References

UniProt :accession O75145