liprin-alpha-2; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2; PTPRF-interacting protein alpha-2 (PPFIA2)

Function: - alters PTPRF cellular localization & induces PTPRF clustering - may regulate disassembly of focal adhesions - may localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment & their association with substrates - forms homodimers & heterodimers with liprins-alpha & liprins-beta - interacts with the second PTPase domain of PTPRD, PTPRF & PTPRS Structure: - the N-terminal coiled coil regions mediate homodimerization preferentially & heterodimerization type alpha/alpha - the C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta & interaction with PTPRD, PTPRF & PTPRS - belongs to the liprin family, liprin-alpha subfamily - contains 3 SAM (sterile alpha motif) domains Compartment: - cytoplasm, cell surface - colocalizes with PTPRF at the cytoplasmic face of the plasma membrane Expression: expressed only in brain

Properties

SIZE: entity length = 1257 aa MW = 143 kD COMPARTMENT: cytoplasm MOTIF: coiled coil {29-154} glutamate-rich region {115-528} MOTIF: glutamate residue (SEVERAL) coiled coil {185-541} MOTIF: Ser phosphorylation site {S538} coiled coil {643-695} MOTIF: Ser phosphorylation site {S689} Ser phosphorylation site {S774} sterile alpha motif NAME: sterile alpha motif SITE: 898-964 sterile alpha motif NAME: sterile alpha motif SITE: 1020-1084 coiled coil {1081-1107} SAM 3 {1108-1177}

Database Correlations

OMIM 603143 UniProt O75334 PFAM correlations Entrez Gene 8499 Kegg hsa:8499

References

UniProt :accession O75334