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mediator of RNA polymerase II transcription subunit 1; activator-recruited cofactor 205 kD component; ARC205; mediator complex subunit 1; peroxisome proliferator-activated receptor-binding protein; PBP; PPAR-binding protein; thyroid hormone receptor-associated protein complex 220 kD component; trap220; thyroid receptor-interacting protein 2; TR-interacting protein 2; TRIP-2; vitamin D receptor-interacting protein complex component DRIP205; p53 regulatory protein RB18A (MED1, ARC205, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2)

Function: - component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes - phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability & promote entry into the nucleolus - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with GATA1 & YWHAH (putative) - specifically interacts with a number of nuclear receptors (ligand-dependent) including AR, ESR1, ESR2, PPARA, PPARG, RXRA, RXRG, THRA, THRB & VDR - interacts with CTNNB1, GABPA, GLI3, PPARGC1A & TP53 - binds DNA Structure: - belongs to the mediator complex subunit 1 family Compartment: - nucleus - a subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3 Alternative splicing: named isoforms=2 Expression: ubiquitously expressed

General

DNA-binding protein phosphoprotein thyroid hormone receptor interacting protein (TRIP)

Properties

SIZE: entity length = 1581 aa MW = 168 kD COMPARTMENT: cell nucleus MOTIF: Mediator/THRA interaction {1-670} MOTIF: ESR1 interaction {16-590} Ser phosphorylation site {S18} Mediator interaction {108-212} Mediator interaction {215-390} THRA interaction {405-644} VDR interaction {542-789} MOTIF: LXXLL motif 1 {604-608} PPARGC1A/THRA interaction {622-701} GATA1 interaction {637-716} LXXLL motif 2 {645-649} ESR1 interaction {656-1066} MOTIF: Ser phosphorylation site {S664} Ser phosphorylation site {S770} Ser phosphorylation site {S771} Ser phosphorylation site {S772} Ser phosphorylation site {S774} Ser phosphorylation site {S795} Thr phosphorylation site {T805} Ser phosphorylation site {S953} Thr phosphorylation site {T1032} Ser phosphorylation site {S1049} Thr phosphorylation site {T1051} Thr phosphorylation site {T1057} serine-rich region {1078-1482} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S1134} Ser phosphorylation site {S1155} Ser phosphorylation site {S1207} Thr phosphorylation site {T1215} Ser phosphorylation site {S1223} Ser phosphorylation site {S1232} TP53 interaction {1249-1421} Ser phosphorylation site {S1252} Ser phosphorylation site {S1403} Ser phosphorylation site {S1433} Ser phosphorylation site {S1439} Thr phosphorylation site {T1440} Thr phosphorylation site {T1457} Ser phosphorylation site {S1463} Ser phosphorylation site {S1479} Ser phosphorylation site {S1481} Ser phosphorylation site {S1482} lysine-rich region {1496-1529} MOTIF: lysine residue (SEVERAL)

Database Correlations

OMIM 604311 UniProt Q15648 Pfam PF10744 Entrez Gene 5469 Kegg hsa:5469

References

  1. Corton JC, Anderson SP, Stauber A. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu Rev Pharmacol Toxicol. 2000;40:491-518. Review. PMID: 10836145
  2. UniProt :accession Q15646

Component-of

MED8 mediator complex (mediator of RNA polymerase 2 transcription)