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serine/threonine protein phosphatase PP1-alpha catalytic subunit; PP-1A (PPP1CA, PPP1A)

Function: - one of 3 alternate catalytic subunits of protein phosphatase 1 (PP1) - component of the PTW/PP1 phosphatase complex - component of the MLL5-L complex - part of a complex containing PPP1R15B, PP1 & NCK1/2 - forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX & NCOA5 - interacts with PPP1R9A & PPP1R9B - interacts with YLPM1 - interacts with NOM1 & PPP1R8 - interacts with HHV-1 ICP34.5 - interacts with PPP1R16B. - interacts with RPSA only in the presence of PPP1R16B - interacts with PPP1R10/PNUTS & PPP1R8 - interacts with WDR82 in the presence of PPP1R10/PNUTS Cofactor: - binds 1 iron ion per subunit (putative) - binds 1 Mn+2 per subunit (putative) phosphoprotein + H2O = a protein + phosphate Structure: - belongs to the PPP phosphatase family, PP-1 subfamily Compartment: - cytoplasm, nucleus, nucleoplasm, nucleolus - primarily nuclear & largely excluded from the nucleolus - highly mobile in cells & can be relocalized through interaction with targeting subunits - NOM1 plays a role in targeting this protein to the nucleolus - in the presence of PPP1R8, relocalizes from the nucleus to nuclear speckles

Related

MLL5-L complex phosphatase-1 (PP1) PTW/PP1 phosphatase complex

General

phosphatase-1 catalytic subunit

Properties

SIZE: entity length = 330 aa MW = 38 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Iron [Fe]-binding site SITE: 64-64 Iron [Fe]-binding site SITE: 66-66 Iron [Fe]-binding site SITE: 92-92 MOTIF: manganese [Mn]-binding site SITE: 92-92 manganese [Mn]-binding site SITE: 124-124 histidine residue {H125} manganese [Mn]-binding site SITE: 173-173 manganese [Mn]-binding site SITE: 248-248 Tyr phosphorylation site {Y306} Thr phosphorylation site {T320} STATE: active state

Database Correlations

OMIM 176875 UniProt P62136 Pfam PF00149 Entrez Gene 5499 KEGG correlations ENZYME 3.1.3.16

References

  1. UniProt :accession P62136
  2. Protein Spotlight; Note: the things we forget -Issue 32 of March 2003 http://www.expasy.org/spotlight/back_issues/sptlt032.shtml

Component-of

PTW/PP1 phosphatase complex