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POU domain class 4, transcription factor 3; brain-specific homeobox/POU domain protein 3C; POU domain transcription factor BRN3C (POU4F3)
Function:
- may play a role in determining or maintaining the identities of a small subset of visual system neurons
Structure:
- belongs to the POU transcription factor family, class-4 subfamily
- contains 1 homeobox DNA-binding domain
- contains 1 POU-specific domain
Compartment: nucleus
Expression: brain. seems to be specific to the retina
Pathology:
- defects in POU4F3 are the cause of non-syndromic autosomal dominant sensorineural deafness 15
General
POU protein
Properties
SIZE: entity length = 338 aa
MW = 37 kD
COMPARTMENT: cell nucleus
MOTIF: POU-IV box {56-65}
POU domain
SITE: 179-256
homeodomain
SITE: 274-333
Database Correlations
OMIM correlations
MORBIDMAP 602460
UniProt Q15319
PFAM correlations
Kegg hsa:5459
References
- OMIM :accession 602460
- Hereditary hearing loss homepage; Note: gene page
http://webhost.ua.ac.be/hhh/
- UniProt :accession Q15319