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POU domain class 4, transcription factor 2; brain-specific homeobox/POU domain protein 3B, POU domain transcription factor BRN3B (POU4F2)
Function:
- may play a role in determining or maintaining the identities of a small subset of visual system neurons
Structure:
- belongs to the POU transcription factor family, class-4 subfamily
- contains 1 homeobox DNA-binding domain
- contains 1 POU-specific domain
Compartment: nucleus
Expression: brain, seems to be specific to the retina
General
POU protein
Properties
SIZE: entity length = 410 aa
MW = 43 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {43-51}
MOTIF: serine residue (SEVERAL)
glycine-rich region {54-69}
serine-rich region {71-80}
MOTIF: serine residue (SEVERAL)
glycine-rich region {81-84}
POU-IV box {111-120}
histidine-rich region {127-130}
MOTIF: histidine residue (SEVERAL)
serine-rich region {156-159}
MOTIF: serine residue (SEVERAL)
histidine-rich region {172-183}
MOTIF: histidine residue (SEVERAL)
POU domain
SITE: 251-328
homeodomain
SITE: 346-405
Database Correlations
OMIM 113725
UniProt Q12837
PFAM correlations
Kegg hsa:5458
References
UniProt :accession Q12837